Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation

被引：21

作者：

Bodiwala, D

Luscombe, CJ

French, ME

Liu, S

Saxby, MF

Jones, PW

Fryer, AA

Strange, RC

机构：

[1] Keele Univ, Sch Med, N Staffordshire Hosp, Clin Biochem Res Lab, Keele, Staffs, England

[2] Univ Keele, Dept Math, Keele ST5 5BG, Staffs, England

来源：

CANCER LETTERS | 2003年 / 200卷 / 02期

关键词：

benign prostatic hypertrophy; prostate cancer; adult sunbathing; childhood sunburning; cumulative exposure; skin type;

D O I：

10.1016/S0304-3835(03)00416-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Low sunlight exposure confers increased prostate cancer risk. In a study conducted in northern England, we investigated how combinations of exposure measures affect this risk. Recursive partitioning was used to identify combinations of exposure parameters that distinguished 453 prostate cancers from 312 benign hypertrophy patients. Sunbathing score most significantly defined cancer patients; 78.7% men with low scores (less than or equal to3.0) and 40.2% men with high scores (>8.0) had cancer. These subgroups were stratified by childhood sunburning, holidays in a hot climate and skin type such that subgroups with a 13.0-fold increased risk of cancer were identified. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 148

页数：8

共 18 条

[1] Susceptibility to prostate cancer: studies on interactions between UVR exposure and skin type [J].