Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat

被引：28

作者：

Amann, R

Schuligoi, R

Lanz, I

Peskar, BA

机构：

[1] Dept. of Exp. and Clin. Pharmacology, University of Graz, 8010 Graz

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 306卷 / 1-3期

关键词：

leukotriene; NGF (nerve growth factor); thermal hyperalgesia;

D O I：

10.1016/0014-2999(96)00255-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Intraplantar injection of mouse beta (2.5S) nerve growth factor (NGF) caused thermal hyperalgesia and stimulated release of immunoreactive leukotriene B-4 from the rat paw skin. Both effects of NGF were prevented by the 5-lipoxygenase inhibitor, (R)-2-[4-quinolin-2-yl-methoxyl)phenyl]-2-cyclopentyl acetic acid (BAY X1005). BAY X1005 did not affect bradykinin-induced thermal hyperalgesia. These results suggest the participation of 5-lipoxygenase products of arachidonate in NGF-induced local thermal hyperalgesia.

引用

收藏

页码：89 / 91

页数：3

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