The protective efficacy aganist Schistosoma japonicum infection by immunization with DNA vaccine and levamisole as adjuvant in mice

被引：17

作者：

Wang, Xiao ^{[2
]}

Jin, Huali ^{[2
]}

Du, Xiaogang ^{[2
]}

Cai, Chun ^{[1
]}

Yu, Yang ^{[2
]}

Zhao, Gan ^{[2
]}

Su, Baowei ^{[2
]}

Huang, Shan ^{[2
]}

Hu, Yanxin ^{[3
]}

Luo, Dongmei ^{[3
]}

She, Ruiping ^{[3
]}

Luo, Xinsong ^{[4
]}

Zeng, Xianfang ^{[1
]}

Yi, Xinyuan ^{[1
]}

Wang, Bin ^{[2
]}

机构：

[1] Cent S Univ, Xiangya Sch Med, Dept Parasitol, Changsha 410008, Peoples R China

[2] China Agr Univ, Coll Biol Sci, State Key Lab Agro Biotechnol, Beijing 100094, Peoples R China

[3] China Agr Univ, Coll Vet Med, Beijing 100094, Peoples R China

[4] Hunan Inst Schistosomiasis Control, Yueyang, Peoples R China

来源：

VACCINE | 2008年 / 26卷 / 15期

关键词：

immune response; Schistosoma japonicum; DNA vaccine; levamisole; gramulomas formation;

D O I：

10.1016/j.vaccine.2008.01.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Levamisole (LMS) as an adjuvant enhances cell-mediated immunity in DNA vaccination; we investigated the efficacy and liver immunopathology alleviation of a DNA vaccine, VR1012-SjGST-32, in a LMS formulation in the murine challenge model. Compared to controls, the VR1012-SjGST-32 plus LMS can reduce worm and egg burdens, as welt as, immunopathological complications associated chronic inflammation significantly in liver, which were apparently associated with Th1-type response. Together, these results suggest that the LMS as a potential Schistosome DNA vaccine adjuvant can enhance both worm killing and disease prevention, which is possibly mediated through the induction of a strong Th1-dominant environment in immunized mice. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1832 / 1845

页数：14

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