Neural stem cells in the mammalian eye: types and regulation

被引：84

作者：

Ahmad, I ^{[1
]}

Das, AV ^{[1
]}

James, J ^{[1
]}

Bhattacharya, S ^{[1
]}

Zhao, X ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Ophthalmol, Lied Transplantat Ctr 11715, Omaha, NE 68198 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 01期

关键词：

retina; ciliary epithelium; Notch; Wnt; hedgehog;

D O I：

10.1016/j.semcdb.2003.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neural stem cells/progenitors that give rise to neurons and glia have been identified in different regions of the brain, including the embryonic retina. Recently, such cells have been reported to be present, in a mitotically quiescent state, in the ciliary epithelium of the adult mammalian eye. The retinal and ciliary epithelium stem cells/progenitors appear to share similar signaling pathways that are emerging as important regulators of stem cells in general. Yet, they are different in certain respects, such as in the potential to self-renew. These two neural stem cell/progenitor populations not only will serve as models for investigating stem cell biology but also will help explain the relationships between embryonic and adult neural stem cells/progenitors. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：53 / 62

页数：10

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