New persubstituted 1,3,5-trisethynyl benzenes via Sonogashira coupling

被引：14

作者：

Hennrich, G ^{[1
]}

Echavarren, AM ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, Madrid 28049, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 06期

关键词：

Sonogashira coupling; molecular scaffolding; crowded benzenes; acetylene compounds;

D O I：

10.1016/j.tetlet.2003.12.011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from 1,3,5-trifluoro-2,4,6-triiodobenzene, selective Sonogashira coupling gave trisalkynylbenzenes, which can be further functionalized making use of the reactive fluorine substituents on the benzene core. Along the way, a conceivably trivial deprotection step unexpectedly led to a pentasubstituted benzene derivative the structure of which was revealed by X-ray crystallography. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1147 / 1149

页数：3

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