Quercetin Inhibits Peripheral and Spinal Cord Nociceptive Mechanisms to Reduce Intense Acute Swimming-Induced Muscle Pain in Mice

被引：45

作者：

Borghi, Sergio M. ^{[1
]}

Pinho-Ribeiro, Felipe A. ^{[1
]}

Fattori, Victor ^{[1
]}

Bussmann, Allan J. C. ^{[2
]}

Vignoli, Josiane A. ^{[3
]}

Camilios-Neto, Doumit ^{[3
]}

Casagrande, Rubia ^{[4
]}

Verri, Waldiceu A., Jr. ^{[1
]}

机构：

[1] Univ Estadual Londrina, Dept Ciencias Patol, Ctr Ciencias Biol, Rodovia Celso Garcia Cid,Km 380,PR445, BR-86057970 Londrina, Parana, Brazil

[2] Univ Estadual Londrina, Lab Anat Patol, Ctr Ciencias Saude, Univ Hosp, Ave Robert Koch 60, BR-86039440 Londrina, Parana, Brazil

[3] Univ Estadual Londrina, Dept Bioquim & Biotecnol, Ctr Ciencias Exatas, Rodovia Celso Garcia Cid,Km 380,PR445, BR-86057970 Londrina, Parana, Brazil

[4] Univ Estadual Londrina, Dept Ciencias Farmaceut, Ctr Ciencias Exatas, Univ Hosp, Ave Robert Koch 60, BR-86039440 Londrina, Parana, Brazil

来源：

PLOS ONE | 2016年 / 11卷 / 09期

关键词：

NF-KAPPA-B; INDUCED OXIDATIVE STRESS; INDUCED INFLAMMATION; NRF2; EXPRESSION; TNF-ALPHA; HYPERALGESIA; EXERCISE; SUPEROXIDE; SUPPLEMENTATION; ACTIVATION;

D O I：

10.1371/journal.pone.0162267

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The present study aimed to evaluate the effects of the flavonoid quercetin (3,3', 4', 5,7-pen-tahydroxyflavone) in a mice model of intense acute swimming-induced muscle pain, which resembles delayed onset muscle soreness. Quercetin intraperitoneal (i.p.) treatment dose-dependently reduced muscle mechanical hyperalgesia. Quercetin inhibited myelo-peroxidase (MPO) and N-acetyl-beta-D-glucosaminidase (NAG) activities, cytokine production, oxidative stress, cyclooxygenase-2 (COX-2) and gp91(phox) mRNA expression and muscle injury (creatinine kinase [CK] blood levels and myoblast determination protein [MyoD] mRNA expression) as well as inhibited NF kappa B activation and induced Nrf2 and HO-1 mRNA expression in the soleus muscle. Beyond inhibiting those peripheral effects, quercetin also inhibited spinal cord cytokine production, oxidative stress and glial cells activation (glial fibrillary acidic protein [GFAP] and ionized calcium-binding adapter molecule 1 [Iba-1] mRNA expression). Concluding, the present data demonstrate that quercetin is a potential molecule for the treatment of muscle pain conditions related to unaccustomed exercise.

引用

页数：23

共 70 条

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