Neuronal nicotinic receptors: from protein structure to function

被引：148

作者：

Itier, V ^{[1
]}

Bertrand, D ^{[1
]}

机构：

[1] CMU, Dept Physiol, CH-1211 Geneva 4, Switzerland

来源：

FEBS LETTERS | 2001年 / 504卷 / 03期

关键词：

neuronal nicotinic acetylcholine receptor; ligand-gated channel; transmission; molecular structure;

D O I：

10.1016/S0014-5793(01)02702-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuronal nicotinic acetylcholine receptors are a prototype of ligand-gated channels that mediate transmission in the central and peripheral nervous system. Structure-function studies performed at the amino acid level are now unraveling the determinant residues either for the properties of the ligand-binding domain or the ionic pore. In this work we review, in the light of the latest finding, the structure-function relationship of these receptors and their implication in neurological diseases. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

收藏

页码：118 / 125

页数：8

相关论文

共 96 条

[1] CALCIUM PERMEABILITY AND MODULATION OF NICOTINIC ACETYLCHOLINE RECEPTOR-CHANNELS IN RAT PARASYMPATHETIC NEURONS [J].

ADAMS, DJ ;

NUTTER, TJ .

JOURNAL OF PHYSIOLOGY-PARIS, 1992, 86 (1-3) :67-76

[2] ENDPLATE CHANNEL OPENING AND THE KINETICS OF QUINACRINE (MEPACRINE) BLOCK [J].

ADAMS, PR ;

FELTZ, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1980, 306 (SEP) :283-306

[3] Electrostatics and the ion selectivity of ligand-gated channels [J].

Adcock, C ;

Smith, GR ;

Sansom, MSP .

BIOPHYSICAL JOURNAL, 1998, 75 (03) :1211-1222

[4] IDENTIFICATION OF ACETYLCHOLINE-RECEPTOR CHANNEL-LINING RESIDUES IN THE ENTIRE M2 SEGMENT OF THE ALPHA-SUBUNIT [J].

AKABAS, MH ;

KAUFMANN, C ;

ARCHDEACON, P ;

KARLIN, A .

NEURON, 1994, 13 (04) :919-927

[5] STUDIES ON THE MECHANISM OF ACTION OF ACETYLCHOLINE ANTAGONISTS ON RAT PARASYMPATHETIC GANGLION-CELLS [J].

ASCHER, P ;

LARGE, WA ;

RANG, HP .

JOURNAL OF PHYSIOLOGY-LONDON, 1979, 295 (OCT) :139-170

[6] Chick optic lobe contains a developmentally regulated α2α5β2 nicotinic receptor subtype [J].

Balestra, B ;

Vailati, S ;

Moretti, M ;

Hanke, W ;

Clementi, F ;

Gotti, C .

MOLECULAR PHARMACOLOGY, 2000, 58 (02) :300-311

[7] GENOMIC SEQUENCES ENCODING THE ALPHA-SUBUNIT OF ACETYLCHOLINE-RECEPTOR ARE CONSERVED IN EVOLUTION [J].

BALLIVET, M ;

NEF, P ;

STALDER, R ;

FULPIUS, B .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1983, 48 :83-87

[8] ELECTROPHYSIOLOGY OF A CHICK NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR EXPRESSED IN XENOPUS OOCYTES AFTER CDNA INJECTION [J].

BALLIVET, M ;

NEF, P ;

COUTURIER, S ;

RUNGGER, D ;

BADER, CR ;

BERTRAND, D ;

COOPER, E .

NEURON, 1988, 1 (09) :847-852

[9] An α4β4 nicotinic receptor subtype is present in chick retina:: Identification, characterization and pharmacological comparison with the transfected α4β4 and α6β4 subtypes [J].

Barabino, B ;

Vailati, S ;

Moretti, M ;

McIntosh, JM ;

Longhi, R ;

Clementi, F ;

Gotti, C .

MOLECULAR PHARMACOLOGY, 2001, 59 (06) :1410-1417

[10] MUTATIONS AT 2 DISTINCT SITES WITHIN THE CHANNEL DOMAIN M2 ALTER CALCIUM PERMEABILITY OF NEURONAL ALPHA-7 NICOTINIC RECEPTOR [J].

BERTRAND, D ;

GALZI, JL ;

DEVILLERSTHIERY, A ;

BERTRAND, S ;

CHANGEUX, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (15) :6971-6975

← 1 2 3 4 5 6 7 8 9 10 →