Molecular correlates of the murine Xce locus

被引:24
作者
Avner, P [1 ]
Prissette, M [1 ]
Arnaud, D [1 ]
Courtier, B [1 ]
Cecchi, C [1 ]
Heard, E [1 ]
机构
[1] Inst Pasteur, Unit Genet Mol Murine, F-75724 Paris 15, France
关键词
D O I
10.1017/S0016672398003516
中图分类号
Q3 [遗传学];
学科分类号
071007 [遗传学]; 090102 [作物遗传育种];
摘要
The murine Xce locus, first identified by Bruce Cattanach, influences the primary choice of the X chromosome to be inactivated. Methylation of a GC-rich region (DXPas34) that includes multiple 34 bp repeats and lies some 15 kb 3' to Xist has been shown to vary with Xce haplotype. The degree of methylation on the active X chromosome at this locus represents one of the few molecular correlates of Xce action currently available. Data relating to the specificity and other characteristics of this association are presented.
引用
收藏
页码:217 / 224
页数:8
相关论文
共 53 条
[1]
AUFFRAY C, 1980, EUR J BIOCHEM, V107, P303
[2]
AVNER P, 1996, EPIGENETIC MECH GENE, P249
[3]
X-CHROMOSOME METHYLATION IN MANIFESTING AND HEALTHY CARRIERS OF DYSTROPHINOPATHIES - CONCORDANCE OF ACTIVATION RATIOS AMONG FIRST DEGREE FEMALE RELATIVES AND SKEWED INACTIVATION AS CAUSE OF THE AFFECTED PHENOTYPES [J].
AZOFEIFA, J ;
VOIT, T ;
HUBNER, C ;
CREMER, M .
HUMAN GENETICS, 1995, 96 (02) :167-176
[4]
Belmont JW, 1996, AM J HUM GENET, V58, P1101
[5]
CHARACTERIZATION OF A MURINE GENE EXPRESSED FROM THE INACTIVE X-CHROMOSOME [J].
BORSANI, G ;
TONLORENZI, R ;
SIMMLER, MC ;
DANDOLO, L ;
ARNAUD, D ;
CAPRA, V ;
GROMPE, M ;
PIZZUTI, A ;
MUZNY, D ;
LAWRENCE, C ;
WILLARD, HF ;
AVNER, P ;
BALLABIO, A .
NATURE, 1991, 351 (6324) :325-329
[6]
CONSERVATION OF POSITION AND EXCLUSIVE EXPRESSION OF MOUSE XIST FROM THE INACTIVE X-CHROMOSOME [J].
BROCKDORFF, N ;
ASHWORTH, A ;
KAY, GF ;
COOPER, P ;
SMITH, S ;
MCCABE, VM ;
NORRIS, DP ;
PENNY, GD ;
PATEL, D ;
RASTAN, S .
NATURE, 1991, 351 (6324) :329-331
[7]
THE PRODUCT OF THE MOUSE XIST GENE IS A 15 KB INACTIVE X-SPECIFIC TRANSCRIPT CONTAINING NO CONSERVED ORF AND LOCATED IN THE NUCLEUS [J].
BROCKDORFF, N ;
ASHWORTH, A ;
KAY, GF ;
MCCABE, VM ;
NORRIS, DP ;
COOPER, PJ ;
SWIFT, S ;
RASTAN, S .
CELL, 1992, 71 (03) :515-526
[8]
A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].
BROWN, CJ ;
BALLABIO, A ;
RUPERT, JL ;
LAFRENIERE, RG ;
GROMPE, M ;
TONLORENZI, R ;
WILLARD, HF .
NATURE, 1991, 349 (6304) :38-44
[9]
THE HUMAN XIST GENE - ANALYSIS OF A 17 KB INACTIVE X-SPECIFIC RNA THAT CONTAINS CONSERVED REPEATS AND IS HIGHLY LOCALIZED WITHIN THE NUCLEUS [J].
BROWN, CJ ;
HENDRICH, BD ;
RUPERT, JL ;
LAFRENIERE, RG ;
XING, Y ;
LAWRENCE, J ;
WILLARD, HF .
CELL, 1992, 71 (03) :527-542
[10]
BUZIN CH, 1994, DEVELOPMENT, V120, P3529