Protein-membrane interaction probed by single plasmonic nanoparticles

被引：88

作者：

Baciu, Cristina L. ^{[1
]}

Becker, Jan ^{[1
]}

Janshoff, Andreas ^{[1
]}

Soennichsen, Carsten ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Phys Chem, D-55128 Mainz, Germany

来源：

NANO LETTERS | 2008年 / 8卷 / 06期

关键词：

D O I：

10.1021/nl080805l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a nanosized and addressable sensor platform based on membrane coated plasmonic particles and show unequivocally the covering with lipid bilayers as well as the subsequent detection of streptavidin binding to biotinylated lipids. The binding is detected on membrane covered gold nanorods by monitoring the spectral shift by fast single particle spectroscopy (fastSPS) on many particles in parallel. Our approach allows for local analysis of protein interaction with biological membranes as a function of the lateral composition of phase separated membranes.

引用

页码：1724 / 1728

页数：5

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