Aging (not so) gracefully

被引：12

作者：

Bickel, SE ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 12期

关键词：

D O I：

10.1038/ng1205-1303

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although the correlation between maternal age and meiotic nondisjunction in human oocytes is widely recognized, the underlying molecular defects are largely unknown. New evidence from mice lacking SMC1 beta suggests that high levels of chromosome mis-segregation in older oocytes may be due in part to deterioration of meiotic sister-chromatid cohesion during aging.

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页码：1303 / 1304

页数：3

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