Crosslinking of alginic acid/chitosan matrices using polycarboxylic acids and their utilization for sodium diclofenac release

被引：48

作者：

Fahmy, H. M. ^{[1
]}

Fouda, Moustafa M. G. ^{[1
]}

机构：

[1] Natl Res Ctr, Textile Res Div, Cairo, Egypt

来源：

CARBOHYDRATE POLYMERS | 2008年 / 73卷 / 04期

关键词：

alginic acid; chitosan; crosslinking; citric acid; swelling properties; drug release; sodium diclofenac;

D O I：

10.1016/j.carbpol.2007.12.024

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three different ratios of alginic acid/chitosan matrices of ratios 3/1, 1/1 and 1/2, respectively, were crosslinked in their dry state using citric acid (CA)/sodium hypophosphite (SHP) at different conditions controlling the crosslinking process such as citric acid concentration, citric acid/sodium hypophosphite molar ratio as well as time and temperature of reaction. Results indicate that such matrices were crosslinked efficiently on curing at 180 degrees C for 9 min in presence of CA/SHP ratio I and the citric acid concentration of 0.6 based on the weight of any matrices. The crosslinked matrices were characterized by investigating their swelling properties, FT-IR and thermalgravimetric analysis. Furthermore, such crosslinked matrices were tested as drug release for sodium diclofenac. (C) 2008 Published by Elsevier Ltd.

引用

页码：606 / 611

页数：6

共 17 条

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