Role of cholesterol and lipid organization in disease

被引：1047

作者：

Maxfield, FR

Tabas, I

机构：

[1] Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA

[2] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Cell Biol, New York, NY 10032 USA

[4] Columbia Univ Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

来源：

NATURE | 2005年 / 438卷 / 7068期

关键词：

D O I：

10.1038/nature04399

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Membrane lipids are essential for biological functions ranging from membrane trafficking to signal transduction. The composition of lipid membranes influences their organization and properties, so it is not surprising that disorders in lipid metabolism and transport have a role in human disease. Significant recent progress has enhanced our understanding of the molecular and cellular basis of lipid- associated disorders such as Tangier disease, Niemann - Pick disease type C and atherosclerosis. These insights have also led to improved understanding of normal physiology.

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页码：612 / 621

页数：10

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