Synthesis of trisubstituted imidazoles by palladium-catalyzed cyclization of O-pentafluorobenzoylamidoximes:: Application to amino acid mimetics with a C-terminal imidazole

被引：122

作者：

Zaman, S

Mitsuru, K

Abell, AD

机构：

[1] Univ Canterbury, Dept Chem, Christchurch, New Zealand

[2] Univ Tokyo, Grad Sch Sci, Bunkyo Ku, Tokyo, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 04期

关键词：

D O I：

10.1021/ol047628p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-Benzyl-4-methylimidazoles with a range of substituents at the 2-position are prepared from O-pentafluorobenzoylamidoximes on treatment with catalytic amounts of Pd(PPh3)(4) and triethylamine. The sequence provides access to optically active amino acid mimetics with a C-terminal imidazole.

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页码：609 / 611

页数：3

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