Bioactive saponins from Swartzia schomburgkii from the Suriname rainforest

被引:30
作者
Abdel-Kader, MS
Bahler, BD
Malone, S
Werkhoven, MCM
Wisse, JH
Neddermann, KM
Bursuker, I
Kingston, DGI [1 ]
机构
[1] Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Wallingford, CT 06492 USA
[3] Conservat Int Suriname, Paramaribo, Suriname
[4] Natl Herbarium Suriname, Paramaribo, Suriname
[5] Cimmissaris Roblesweg, Bedrijf Geneesmiddelen Voorziening Suriname, Geyersvlijt, Suriname
来源
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 11期
关键词
D O I
10.1021/np0000926
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioassay-guided fractionation of the MeOH extract of Swartzia schomburgkii using the engineered yeast strains 1138, 1140, and 1353 as the bioassay tool resulted in the isolation of five, active (2, 4-7) and three inactive (1, 3, 8) saponins. Saponins 4 and 6 are previously unreported. The structures of all of the saponins were established based on 1D and 2D NMR spectral analysis, on acid and alkaline hydrolysis followed by TLC and GC-MS, and by comparison with literature data for known compounds. Three of the isolated compounds (4-6) showed weak cytotoxicity against the M-109 cell line.
引用
收藏
页码:1461 / 1464
页数:4
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