Association of an early respiratory syncytial virus infection and atopic allergy

被引:39
作者
Juntti, H
Kokkonen, J
Dunder, T
Renko, M
Niinimäki, A
Uhari, M
机构
[1] Oulu Univ, Dept Pediat, FIN-90014 Oulu, Finland
[2] Oulu Univ, Dept Dermatol, FIN-90014 Oulu, Finland
关键词
asthma; atopy; respiratory syncytial virus; skin-prick test;
D O I
10.1034/j.1398-9995.2003.00233.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Respiratory syncytial virus (RSV) causes postbronchiolitic wheezing but its role in allergic sensitization is controversial. The purpose of the study was to examine the effect of an early RSV infection on allergic sensitization. Methods: Seventy-six subjects were examined 6-10 years after hospitalization for RSV infection during the first year of life. Fifty-one subjects (68%) attended clinical studies and 25 filled in a questionnaire. The study protocol included lung function, skin-prick and blood tests. The controls were matched for birth date and sex. Results: Eight per cent of the subjects and 37% of the controls had at least one positive skin-prick test (SPT) (difference -35%, 95% CI -50 to -19%, P<0.0001). Allergic rhinitis, atopic dermatitis and asthma occurred as often in both groups, but asthma had been diagnosed significantly earlier in the subjects than in the controls [mean age 3.0 years (SD 2.6) and 5.6 years (SD 3.0), difference 2.6 years, 95% CI 0.57-4.65, P=0.014]. In a logistic regression analysis, RSV infection was associated with negative SPTs. Conclusions: An early RSV infection results in reduction of SPT positivity but not of occurrence of atopic diseases. This finding might explain why there is less atopic sensitization in countries with a greater probability of acquiring RSV infection at an early age.
引用
收藏
页码:878 / 884
页数:7
相关论文
共 29 条
  • [1] Wheezing in relation to atopy and environmental factors in Estonian and Swedish schoolchildren
    Annus, T
    Björkstén, B
    Mai, XM
    Nilsson, L
    Riikjärv, MA
    Sandin, A
    Bråbäck, L
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2001, 31 (12) : 1846 - 1853
  • [2] INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS
    ASHER, MI
    KEIL, U
    ANDERSON, HR
    BEASLEY, R
    CRANE, J
    MARTINEZ, F
    MITCHELL, EA
    PEARCE, N
    SIBBALD, B
    STEWART, AW
    STRACHAN, D
    WEILAND, SK
    WILLIAMS, HC
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1995, 8 (03) : 483 - 491
  • [3] BJORKSTEN F, 1981, ACTA MED SCAND, V209, P299
  • [4] ACUTE BRONCHIOLITIS - PREDISPOSING FACTORS AND CHARACTERIZATION OF INFANTS AT RISK
    CARLSEN, KH
    LARSEN, S
    BJERVE, O
    LEEGAARD, J
    [J]. PEDIATRIC PULMONOLOGY, 1987, 3 (03) : 153 - 160
  • [5] ANTIGEN-DETECTION IN THE DIAGNOSIS OF VIRAL-INFECTIONS
    HIETALA, J
    UHARI, M
    TUOKKO, H
    [J]. SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 1988, 20 (06) : 595 - 599
  • [6] Koillinen H, 1998, Finnish Medical Journal, V53, P395
  • [7] MAGGI E, 1992, J IMMUNOL, V148, P2142
  • [8] Malmberg P, 2001, Duodecim, V117, P1541
  • [9] Infections preventing atopy: Facts and new questions
    Matricardi, PM
    [J]. ALLERGY, 1997, 52 (09) : 879 - 882
  • [10] Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus
    Matricardi, PM
    Rosmini, F
    Ferrigno, L
    Nisini, R
    Rapicetta, M
    Chionne, P
    Stroffolini, T
    Pasquini, P
    DAmelio, R
    [J]. BRITISH MEDICAL JOURNAL, 1997, 314 (7086) : 999 - 1003