N-acetylaspartate Decrease in Acute Stage of Ischemic Stroke:A Perspective from Experimental and Clinical Studies

被引：27

作者：

Igarashi, Hironaka ^{[1
]}

Suzuki, Yuji ^{[1
]}

Huber, Vincent J. ^{[1
]}

Ida, Masahiro ^{[2
]}

Nakada, Tsutomu ^{[1
]}

机构：

[1] Niigata Univ, Ctr Integrated Human Brain Sci, Brain Res Inst, Niigata 9518585, Japan

[2] Tokyo Metropolitan Ebara Hosp, Dept Radiol, Tokyo, Japan

来源：

MAGNETIC RESONANCE IN MEDICAL SCIENCES | 2015年 / 14卷 / 01期

关键词：

brain; ischemia; magnetic resonance spectroscopy; N-acetylaspartate; ACETYL-L-ASPARTATE; MAGNETIC-RESONANCE-SPECTROSCOPY; FOCAL CEREBRAL-ISCHEMIA; APPARENT DIFFUSION-COEFFICIENT; H-1 MR SPECTROSCOPY; RAT-BRAIN; DIFFERENTIAL DISTRIBUTION; METABOLIC-CHANGES; ARTERY OCCLUSION; AMINO-ACIDS;

D O I：

10.2463/mrms.2014-0039

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

N-acetylaspartate (NAA) appears in a prominent peak in proton magnetic resonance spectroscopy (H-1-MRS) of the brain. Exhibition by NAA of time-dependent attenuation that reflects energy metabolism during the acute stage of cerebral ischemia makes this metabolite a unique biomarker for assessing ischemic stroke. Although magnetic resonance (MR) imaging is a powerful technique for inspecting the pathological changes that occur during ischemic stroke, biomarkers that directly reflect the drastic metabolic changes associated with acute-stage ischemia are strongly warranted for appropriate therapeutic decision-making in daily clinical settings. In this review, we provide a brief overview of NAA metabolism and focus on the use of attenuation in NAA as a means for assessing the pathophysiological changes that occur during the acute stage of ischemic stroke.

引用

页码：13 / 24

页数：12

共 95 条

[1]

Evidence for mitochondrial and cytoplasmic N-acetylaspartate synthesis in SH-SY5Y neuroblastoma cells [J].