Epidemiology of parasitic co-infections during pregnancy in Lambarene, Gabon

被引:78
作者
Adegnika, Ayola A. [1 ,2 ,3 ]
Ramharter, Michael [1 ,3 ,4 ]
Agnandji, Selidji T. [1 ,3 ]
Ngoa, Ulysse Ateba [1 ,3 ]
Issifou, Saadou [1 ,3 ]
Yazdanbahksh, Maria [2 ]
Kremsner, Peter G. [1 ,3 ]
机构
[1] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
[2] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands
[3] Univ Tubingen, Inst Trop Med, Tubingen, Germany
[4] Med Univ Vienna, Div Infect Dis & Trop Med, Dept Med 1, Vienna, Austria
关键词
co-infection; Gabon; helminths; malaria; pregnancy; PLASMODIUM-FALCIPARUM INFECTION; MALARIA-ENDEMIC AREAS; LOW-BIRTH-WEIGHT; SCHISTOSOMA-HAEMATOBIUM; INTESTINAL HELMINTH; PLACENTAL MALARIA; RISK-FACTORS; WOMEN; PREVALENCE; ARTESUNATE;
D O I
10.1111/j.1365-3156.2010.02598.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
OBJECTIVES To evaluate the epidemiologic data of parasitic infections and co-infections in pregnant women in Lambarene, Gabon. METHODS In Lambarene, Gabon - a region of high endemicity for Plasmodium falciparum and helminths - we conducted a longitudinal survey of malaria and helminth infections during pregnancy. RESULTS Of 388 pregnant women included in the study, 98 (25%) experienced at least one episode of P. falciparum infection (incidence of 2.6 infections per year of pregnancy). One hundred and seventy pregnant women (49%) were infected with intestinal helminths, and 41 (12%) harboured Shistosoma haematobium. In total, 230 (65%) pregnant women carried at least one parasitic infection are 74 (22%) harboured at least two or more parasite species. Ascaris lumbricoides and primiparity were independently associated with Plasmodium infection during pregnancy [odds ratio (95% confidence intervals) 2.4, (1.4-3.8); 2.1, (1.3-3.5), respectively]. CONCLUSION This study shows a high burden of parasitic infections with substantial degree of parasitic co-infections in pregnant women in a Central African region. This may have implications for immunological studies and operational research involving pregnant women.
引用
收藏
页码:1204 / 1209
页数:6
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