RNA interference-based strategies for metabolic syndrome treatment

被引：6

作者：

Barthel, A

Herzig, S

Müller, HW

Harborth, J

Bornstein, SR

机构：

[1] Univ Hosp Duesseldorf, Dept Endocrinol Diabetol & Rheumatol, D-40225 Dusseldorf, Germany

[2] German Canc Res Ctr, Dept Mol Metab Control, D-6900 Heidelberg, Germany

[3] Univ Hosp Duesseldorf, Dept Nucl Med, D-40225 Dusseldorf, Germany

[4] Alnylam Pharmaceut, Cambridge, MA USA

[5] Univ Dresden, Dept Med, Dresden, Germany

来源：

HORMONE AND METABOLIC RESEARCH | 2005年 / 37卷 / 02期

关键词：

metabolic syndrome; insulin signaling; hepatic glucose production; adipose tissue; renin-angiotensin-aldosterone system;

D O I：

10.1055/s-2005-861157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

RNA interference is a naturally occurring cellular mechanism to inhibit the expression of specific gene products. The technical application of RNA interference offers great potential for the specific treatment of a huge variety of diseases including the metabolic syndrome, one of the most challenging threats to human health associated with our civilization. In order to develop novel and powerful strategies for the treatment of the metabolic syndrome, it is essential to define a set of specific gene products that may be targeted by RNA interference. Based on currently available in vitro and in vivo data, we discuss the feasibility of candidate genes involved in the pathophysiology of the metabolic syndrome as potential targets for a rational RNA interference based therapy in this review.

引用

收藏

页码：59 / 62

页数：4

相关论文

共 45 条

[1] Regulation of fasted blood glucose by resistin [J].

Banerjee, RR ;

Rangwala, SM ;

Shapiro, JS ;

Rich, AS ;

Rhoades, B ;

Qi, Y ;

Wang, J ;

Rajala, MW ;

Pocai, A ;

Scherer, PE ;

Steppan, CM ;

Ahima, RS ;

Obici, S ;

Rossetti, L ;

Lazar, MA .

SCIENCE, 2004, 303 (5661) :1195-1198

[2] Novel concepts in insulin regulation of hepatic gluconeogenesis [J].

Barthel, A ;

Schmoll, D .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 285 (04) :E685-E692

[3]

Barthel A, 2003, MED KLIN, V98, P283, DOI 10.1007/s00063-003-1258-9

[4] A system for stable expression of short interfering RNAs in mammalian cells [J].

Brummelkamp, TR ;

Bernards, R ;

Agami, R .

SCIENCE, 2002, 296 (5567) :550-553

[5] Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice [J].

Butler, M ;

McKay, RA ;

Popoff, IJ ;

Gaarde, WA ;

Witchell, D ;

Murray, SF ;

Dean, NM ;

Bhanot, S ;

Monia, BP .

DIABETES, 2002, 51 (04) :1028-1034

[6] dsRNA-mediated gene silencing in cultured Drosophila cells:: a tissue culture model for the analysis of RNA interference [J].

Caplen, NJ ;

Fleenor, J ;

Fire, A ;

Morgan, RA .

GENE, 2000, 252 (1-2) :95-105

[7] Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems [J].

Caplen, NJ ;

Parrish, S ;

Imani, F ;

Fire, A ;

Morgan, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (17) :9742-9747

[8] Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with Type II diabetes (UKPDS No. 51) [J].

Clarke, P ;

Gray, A ;

Adler, A ;

Stevens, R ;

Raikou, M ;

Cull, C ;

Stratton, I ;

Holman, R .

DIABETOLOGIA, 2001, 44 (03) :298-304

[9] The lipid phosphatase SHIP2 controls insulin sensitivity [J].

Clément, S ;

Krause, U ;

Desmedt, F ;

Tanti, JF ;

Behrends, J ;

Pesesse, X ;

Sasaki, T ;

Penninger, J ;

Doherty, M ;

Malaisse, W ;

Dumont, JE ;

Le Marchand-Brustel, Y ;

Erneux, C ;

Hue, L ;

Schurmans, S .

NATURE, 2001, 409 (6816) :92-97

[10] TRB3:: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver [J].

Du, KY ;

Herzig, S ;

Kulkarni, RN ;

Montminy, M .

SCIENCE, 2003, 300 (5625) :1574-1577

← 1 2 3 4 5 →