Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans

被引：138

作者：

van der Woude, H ^{[1
]}

Gliszczynska-Swiglo, A

Struijs, K

Smeets, A

Alink, GM

Rietjens, IMCM

机构：

[1] Univ Wageningen & Res Ctr, Div Toxicol, NL-6703 HE Wageningen, Netherlands

[2] Poznan Univ Econ, Fac Commod Sci, PL-60697 Poznan, Poland

来源：

CANCER LETTERS | 2003年 / 200卷 / 01期

关键词：

quercetin; proliferation; biphasic effect; stability; solubility; ascorbic acid;

D O I：

10.1016/S0304-3835(03)00412-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：41 / 47

页数：7

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