Behavior-dependent states of the hippocampal network affect functional clustering of neurons

被引:39
作者
Hirase, H [1 ]
Leinekugel, X [1 ]
Csicsvari, J [1 ]
Czurkó, A [1 ]
Buzsáki, G [1 ]
机构
[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA
关键词
pyramidal cell; interneuron; sleep; synchrony; theta; sharp waves;
D O I
10.1523/JNEUROSCI.21-10-j0003.2001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 <mu>m) pyramidal neurons compared with distant (>300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors.
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页数:4
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