Changes of tissue factor activity on inflammatory stimulus and aging in rat

被引：6

作者：

Han, YN ^{[1
]}

Rhee, IK ^{[1
]}

机构：

[1] Seoul Natl Univ, Inst Nat Prod Res, Seoul 110460, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 05期

关键词：

brain tissue factor; lung tissue factor; inflammatory stimulus; age-related increase of tissue factor;

D O I：

10.1007/BF02975373

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Tissue factor (TF), a principal initiator of the vertebrate coagulation cascade, is expressed in organ tissues, cells and blood. TF is known to be induced in endothelial cells, monocytes and macrophages by inflammatory stimuli and in many pathologic conditions. By using the modified method for in vivo TF activity assay, we found that turpentine oil injection as an inflammatory stimulus also induced the TF activity in lung and brain tissues of rats. And the age-related increase in TF activity was observed in healthy rat brain tissue.

引用

页码：549 / 554

页数：6

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