Brain imaging study of the acute effects of Δ9-tetrahydrocannabinol (THC) on attention and motor coordination in regular users of marijuana

被引：40

作者：

Weinstein, Aviv ^{[1
,2
]}

Brickner, Orit ^{[2
]}

Lerman, Hedva ^{[2
]}

Greemland, Mazal ^{[2
]}

Bloch, Miki ^{[2
]}

Lester, Hava ^{[1
]}

Chisin, Roland ^{[1
]}

Mechoulam, Raphael ^{[1
]}

Bar-Hamburger, Rachel ^{[3
]}

Freedman, Nanette ^{[1
]}

Even-Sapir, Einat ^{[2
]}

机构：

[1] Hadassah Univ Hosp, Dept Med Biophys & Nucl Med, Sch Pharm, IL-91120 Jerusalem, Israel

[2] Sourasky Med Ctr, Dept Nucl Med, Psychiat Serv, Tel Aviv, Israel

[3] Israeli Anti Drug Authority, Jerusalem, Israel

来源：

PSYCHOPHARMACOLOGY | 2008年 / 196卷 / 01期

关键词：

marijuana; THC; attention; motor skills; PET;

D O I：

10.1007/s00213-007-0940-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Procedure Twelve regular users of marijuana underwent two positron emission tomography (PET) scans using [F-18] Fluorodeoxyglucose (FDG), one while subject to the effects of 17 mg THC, the other without THC. In both sessions, a virtual reality maze task was performed during the FDG uptake period. Results When subject to the effects of 17 mg THC, regular marijuana smokers hit the walls more often on the virtual maze task than without THC. Compared to results without THC, 17 mg THC increased brain metabolism during task performance in areas that are associated with motor coordination and attention in the middle and medial frontal cortices and anterior cingulate, and reduced metabolism in areas that are related to visual integration of motion in the occipital lobes. Conclusion These findings suggest that in regular marijuana users, the immediate effects of marijuana may impact on cognitive-motor skills and brain mechanisms that modulate coordinated movement and driving.

引用

页码：119 / 131

页数：13

共 64 条

[1]

[Anonymous], NSDUH SER H

[2]

[Anonymous], 2002, 8 INT C FUNCT MAPP H

[3]

[Anonymous], 1994, AM PSYCHIATR ASSOC

[4] INSENSITIVITY TO FUTURE CONSEQUENCES FOLLOWING DAMAGE TO HUMAN PREFRONTAL CORTEX [J].

BECHARA, A ;

DAMASIO, AR ;

DAMASIO, H ;

ANDERSON, SW .

COGNITION, 1994, 50 (1-3) :7-15

[5] Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex [J].

Bechara, A ;

Tranel, D ;

Damasio, H ;

Damasio, AR .

CEREBRAL CORTEX, 1996, 6 (02) :215-225

[6] EFFECTS OF CHRONIC MARIJUANA USE ON HUMAN COGNITION [J].

BLOCK, RI ;

GHONEIM, MM .

PSYCHOPHARMACOLOGY, 1993, 110 (1-2) :219-228

[7] Cerebellar hypoactivity in frequent marijuana users [J].

Block, RI ;

O'Leary, DS ;

Hichwa, RD ;

Augustinack, JC ;

Ponto, LLB ;

Ghoneim, MM ;

Arndt, S ;

Ehrhardt, JC ;

Hurtig, RR ;

Watkins, GL ;

Hall, JA ;

Nathan, PE ;

Andreasen, NC .

NEUROREPORT, 2000, 11 (04) :749-753

[8] Dose-related neurocognitive effects of marijuana use [J].

Bolla, KI ;

Brown, K ;

Eldreth, D ;

Tate, K ;

Cadet, JL .

NEUROLOGY, 2002, 59 (09) :1337-1343

[9] Cerebral blood flow in depressed patients: a methodological comparison of statistical parametric mapping and region of interest analyses [J].

Bonne, O ;

Louzoun, Y ;

Aharon, I ;

Krausz, Y ;

Karger, H ;

Lerer, B ;

Bocher, M ;

Freedman, N ;

Chisin, R .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2003, 122 (01) :49-57

[10]

BRICKNER O, 2005, COLL DRUG DEP M ORL, P18

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