Superficial and metachronous invasive bladder carcinomas are clonally related

被引:21
作者
Vriesema, JLJ
Aben, KKH
Witjes, JA
Kiemeney, LALM
Schalken, JA
机构
[1] Univ Med Ctr Nijmegen, Dept Urol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Med Ctr Nijmegen, Dept Epidemiol, Nijmegen, Netherlands
关键词
bladder cancer; clonality; field cancerization; p53;
D O I
10.1002/ijc.1402
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Synchronous and metachronous tumors are frequently observed in the urinary tract and may be explained by the concept of 'fieldcancerization,' i.e., exposure to carcinogens leading to the independent transformation of many urothelial cells resulting in oncogenetically unrelated tumors. Increasing evidence, however, supports the concept of clonality, i.e., the progeny of a single transformed cell spreads through the urinary system resulting in genetically related tumors. The aim of our study was to investigate the putative clonal origin of invasive urothelial cell carcinomas (UCCs) of the bladder from a prior superficial tumor. We selected 6 patients (5 males and 1 female) with superficial and subsequent invasive UCC tumors. All patients were previously diagnosed with a p53 mutation in their invasive tumor. At least 1 superficial and 1 invasive tumor of the same patient were analyzed for mutations in the p53 tumor suppressor gene by PCR-SSCP and, in case of a band shift, followed by direct sequencing. In all patients the same p53 mutation was found in the superficial and subsequent invasive tumor(s). All tumors arose from the same progenitor cell. These results support the concept of a clonal origin of superficial and metachronous invasive bladder UCCs. (C) 2001 Wiley-Liss, Inc.
引用
收藏
页码:699 / 702
页数:4
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