p53-independent role of MDM2 in TGF-β1 resistance

被引：190

作者：

Sun, PQ

Dong, P

Dai, K

Hannon, GJ

Beach, D

机构：

[1] Inst Child Hlth, London WC1N, England

[2] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

SCIENCE | 1998年 / 282卷 / 5397期

关键词：

D O I：

10.1126/science.282.5397.2270

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been Linked to tumorigenesis, A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells, Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression Levels correlated with TGF-beta resistance. Thus, MDM2 may confer TGF-beta resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.

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页码：2270 / 2272

页数：3

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