Bronchopulmonary dysplasia is not associated with ultrasound-defined cerebral white matter damage in preterm newborns

被引:10
作者
Dammann, O
Allred, EN
Van Marter, LJ
Dammann, CEL
Leviton, A
机构
[1] Hannover Med Sch, Perinatal Infect Dis Epidemiol Unit, Dept Obstet Prenatal Med & Gynecol, D-30623 Hannover, Germany
[2] Hannover Med Sch, Dept Pediat Pulm & Neonatol, D-30623 Hannover, Germany
[3] Childrens Hosp, Dept Neurol, Neuroepidemiol Unit, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[6] Childrens Hosp, Dept Pediat, Boston, MA 02115 USA
[7] Harvard Univ, Sch Med, Boston, MA 02115 USA
[8] Brigham & Womens Hosp, Div Newborn Med, Boston, MA 02115 USA
[9] Tufts Univ, Sch Med, Dept Pediat, New England Med Ctr,Div Newborn Med, Boston, MA 02111 USA
关键词
D O I
10.1203/01.PDR.0000100906.09524.88
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Bronchopulmonary dysplasia (BPD) and cerebral white matter damage (WMD) are neonatal disorders that occur most commonly in those who are born much before term. In a large multicenter database, we sought to determine whether the two disorders occur together more frequently than expected and whether BPD and other neonatal respiratory characteristics are more common among infants who develop ultrasound-defined WMD than among those who do not. In a sample of 904 infants who were born before the 30th week of gestation and survived until 36 wk postmenstrual age, we did not find a co-occurrence of BPD and WMD above what would be expected by chance. Confounding does not seem to account for this lack of association between WMD and BPD. In conclusion, our findings do not support the hypothesis that BPD contributes to the occurrence of sonographically defined WMD.
引用
收藏
页码:319 / 325
页数:7
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