Clostridium perfringens toxin genotypes in the feces of healthy North Americans

被引：104

作者：

Carman, Robert J. ^{[1
]}

Sayeed, Sameera ^{[2
]}

Li, Jihong ^{[2
]}

Genheimer, Christopher W. ^{[1
]}

Hiltonsmith, Megan F. ^{[1
]}

Wilkins, Tracy D. ^{[1
]}

McClane, Bruce A. ^{[2
]}

机构：

[1] TechLab Inc, Blacksburg, VA 24060 USA

[2] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

来源：

ANAEROBE | 2008年 / 14卷 / 02期

关键词：

Clostridium perfringens; health; genotype; enterotoxin; beta2;

D O I：

10.1016/j.anaerobe.2008.01.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the frequency of Clostridium perfringens in the normal fecal flora of healthy North Americans. About half of 43 subjects were colonized with C perfringens at levels of similar to 10(6) cfu/g feces. Only type A strains were recovered. Spores sometimes outnumbered vegetative cells. Several genotypes were found. Some donors carried two genotypes, some only one. We found no alpha, beta2 or enterotoxin in the stools of any donors. Though some isolates carried toxin genes (e.g. cpe and cpb2) on plasmids, we saw no indication that healthy humans are the reservoir for the chromosomally-borne cpe recovered from cases of C perfringens food poisoning. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：102 / 108

页数：7

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