Change in tissue concentrations of lipid hydroperoxides, vitamin C and vitamin E in rats with streptozotocin-induced diabetes

被引：77

作者：

Sun, F

Iwaguchi, K

Shudo, R

Nagaki, Y

Tanaka, K

Ikeda, K

Tokumaru, S

Kojo, S ^{[2
]}

机构：

[1] Joetsu Univ Educ, Dept Life & Hlth Sci, Niigata 9438512, Japan

[2] Nara Womens Univ, Dept Food Sci & Nutr, Nara 6308506, Japan

来源：

CLINICAL SCIENCE | 1999年 / 96卷 / 02期

关键词：

diabetes; hydroperoxide; vitamin C; vitamin E;

D O I：

10.1042/CS19980189

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

The tissue concentration of lipid hydroperoxides, which was determined by a specific method involving chemical derivatization and HPLC, increased significantly in the heart, liver, kidney and muscle of diabetic rats 8 weeks after the intraperitoneal injection of streptozotocin compared with that of the control group. These results demonstrate that an enhanced oxidative stress is caused in these tissues by diabetes. Vitamin C concentrations of the brain, heart, lung, liver, kidney and plasma of the diabetic rats decreased significantly after 8 weeks compared with those of the control group. Vitamin E concentrations of the brain, heart, liver, kidney, muscle and plasma of the diabetic rats increased significantly after 4 weeks compared with the control group. After 8 weeks, an elevation in vitamin E concentration was observed in the heart, liver, muscle and plasma of the diabetic rats.

引用

页码：185 / 190

页数：6

共 43 条

[1]

SERUM ANTIOXIDANT STATUS IN STREPTOZOTOCIN-INDUCED DIABETIC RAT [J].