NMDA receptor mRNA correlation with antemortem cognitive impairment in schizophrenia

被引:88
作者
Humphries, C
Mortimer, A
Hirsch, S
deBelleroche, J
机构
[1] CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM,LONDON W6 8RF,ENGLAND
[2] CHARING CROSS & WESTMINSTER MED SCH,DEPT PSYCHIAT,LONDON W6 8RF,ENGLAND
关键词
schizophrenia; cognitive function; NMDA receptor; NR-1; mRNA; temporal cortex; gene expression; glutamate;
D O I
10.1097/00001756-199608120-00040
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
WE investigated the expression of the N-methyl-D-aspartate (NMDA) receptor, an important glutamate receptor, in brains from a population of well characterized schizophrenic patients who prospectively consented to tissue donation. Levels of NR-1 mRNA in tissue homogenates of superior temporal cortex were reduced by 30% in cognitively impaired schizophrenic patients compared with controls (p < 0.04), while levels in patients without cognitive impairment showed no such reduction. The NR-1 mRNA deficit was significantly correlated with general cognitive function as rated with the Global Deterioration scale (p < 0.001), the Mini-Mental State examination (p < 0.01) and the premorbid IQ determined using the National Adult Reading Test (NART, p < 0.01). NR-1 mRNA concentration was not correlated with age, sex, pH or postmortem delay in the control and schizophrenia group when analysed separately or combined. There was, therefore, a significant correlation between NR-1 mRNA loss and cognitive deterioration in patients with schizophrenia.
引用
收藏
页码:2051 / 2055
页数:5
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