Structure elucidation of nanogram quantities of unknown designer drugs based on phenylalkylamine derivates by ion trap multiple mass spectrometry

被引：10

作者：

Kölliker, S ^{[1
]}

Oehme, M ^{[1
]}

机构：

[1] Univ Basel, CH-4057 Basel, Switzerland

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2004年 / 378卷 / 05期

关键词：

designer drugs; dimethoxyamphetamine; LC-MSn; MDMA; phenethylamines; trimethoxyamphetamine;

D O I：

10.1007/s00216-003-2411-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Multiple mass spectra (MS1 to MS6) of 55 phenylalkylamine derivatives were recorded with ion-trap mass spectrometry employing electrospray (ESI) and atmospheric pressure chemical ionization (APCI). Fragmentation patterns were studied in detail and a generally applicable scheme was established for elucidation of the structures of phenylalkylamine derivatives. HPLC combined with ion-trap multiple mass spectrometry was used to identify the structure of reaction by-products in ecstasy samples from the "black" market. Low nanogram amounts were sufficient for on-line HPLC-MSn structure elucidation of unknowns.

引用

页码：1294 / 1304

页数：11

共 32 条

[1] Chromatographic and mass spectral methods of identification for the side-chain and ring regioisomers of methylenedioxymethamphetamine [J].