Two novel promoters in the upstream regulatory region of human papillomavirus type 31b are negatively regulated by epithelial differentiation

被引：30

作者：

Ozbun, MA

Meyers, C ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA

[2] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

来源：

JOURNAL OF VIROLOGY | 1999年 / 73卷 / 04期

关键词：

D O I：

10.1128/JVI.73.4.3505-3510.1999

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Organotypic cultures support the stratification and differentiation of keratinocytes and the human papillomavirus (HPV) life cycle. We report transcription from four novel promoters in the HPV31b upstream regulatory region during the viral life cycle in organotypic cultures. Promoter initiation was not differentiation dependent; two promoters were down-regulated upon epithelial differentiation.

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页码：3505 / 3510

页数：6

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