Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress

被引：105

作者：

Augoulea, A. ^{[1
,2
,3
]}

Alexandrou, A. ^{[4
]}

Creatsa, M. ^{[1
]}

Vrachnis, N. ^{[1
,2
,3
]}

Lambrinoudaki, I. ^{[1
]}

机构：

[1] Univ Athens, Aretaieion Hosp, Dept Obstet & Gynecol 2, GR-11526 Athens, Greece

[2] Univ Athens, Gynecol Unit, GR-11526 Athens, Greece

[3] Univ Athens, Evgenideio Hosp, Res Ctr, GR-11526 Athens, Greece

[4] Univ Athens, Laiko Hosp, Dept Surg 1, GR-11526 Athens, Greece

来源：

ARCHIVES OF GYNECOLOGY AND OBSTETRICS | 2012年 / 286卷 / 01期

关键词：

Endometriosis; Oxidative stress; Genetic factors; Inflammation; ESTROGEN-RECEPTOR-ALPHA; ADVANCED-STAGE ENDOMETRIOSIS; PERITONEAL ENDOMETRIOSIS; POSSIBLE INVOLVEMENT; MONOZYGOTIC TWINS; OVARIAN-CANCER; WOMEN; POLYMORPHISMS; INFERTILITY; MARKERS;

D O I：

10.1007/s00404-012-2357-8

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity. The etiology of this multifactorial disease is still unresolved and an increasing number of studies suggest that genetic, hormonal, environmental, immunological and oxidative factors may all play an important role in the pathogenesis of this disorder. In this literature review, inflammatory activity, oxidative stress as well as genetic abnormalities and mutations have been studied in an effort to identify factors predisposing to endometriosis.

引用

页码：99 / 103

页数：5

共 80 条

[41] Estrogen receptor dinucleotide repeat polymorphism is associated with minimal or mild endometriosis [J].

Kim, SH ;

Choi, YM ;

Jun, JK ;

Kim, SH ;

Kim, JG ;

Moon, SY .

FERTILITY AND STERILITY, 2005, 84 (03) :774-777

[42] Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata [J].

Kitawaki, J ;

Obayashi, H ;

Ishihara, H ;

Koshiba, H ;

Kusuki, I ;

Kado, N ;

Tsukamoto, K ;

Hasegawa, G ;

Nakamura, N ;

Honjo, H .

HUMAN REPRODUCTION, 2001, 16 (01) :51-55

[43] Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (Review) [J].

Kobayashi, Hiroshi ;

Kajiwara, Hirotaka ;

Kanayama, Seiji ;

Yamada, Yoshihiko ;

Furukawa, Naoto ;

Noguchi, Taketoshi ;

Haruta, Shoji ;

Yoshida, Shozo ;

Sakata, Mariko ;

Sado, Toshiyuki ;

Oi, Hidekazu .

ONCOLOGY REPORTS, 2009, 22 (02) :233-240

[44] Endometriotic disease: the role of peritoneal fluid [J].

Koninckx, PR ;

Kennedy, SH ;

Barlow, DH .

HUMAN REPRODUCTION UPDATE, 1998, 4 (05) :741-751

[45] The physiopathology of endometriosis: Pollution and dioxin [J].

Koninckx, PR .

GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1999, 47 :47-49

[46]

Lamb K T, 1986, Wis Med J, V85, P27

[47] Measurable serum markers of oxidative stress response in women with endometriosis [J].

Lambrinoudaki, Irene V. ;

Augoulea, Areti ;

Christodoulakos, George E. ;

Economou, Emmanuel V. ;

Kaparos, George ;

Kontoravdis, Antonios ;

Papadias, Constantinos ;

Creatsas, George .

FERTILITY AND STERILITY, 2009, 91 (01) :46-50

[48] Molecular Pathogenesis of Endometriosis; Toll-Like Receptor-4 A896G (D299G) Polymorphism: A Novel Explanation [J].

Latha, Madhavi ;

Vaidya, Sirisha ;

Movva, Sireesha ;

Chava, Srinivas ;

Govindan, Sujatha ;

Govatati, Suresh ;

Banoori, Manjula ;

Hasan, Qurratulain ;

Kodati, Vijay Lakshmi .

GENETIC TESTING AND MOLECULAR BIOMARKERS, 2011, 15 (03) :181-184

[49] Estrogen receptor gene polymorphisms are associated with recurrence of endometriosis [J].

Luisi, S ;

Galleri, L ;

Marini, F ;

Ambrosini, G ;

Brandi, ML ;

Petraglia, F .

FERTILITY AND STERILITY, 2006, 85 (03) :764-766

[50] Possible involvement of hMLH1, p16INK4a and PTEN in the malignant transformation of endometriosis [J].

Martini, M ;

Ciccarone, M ;

Garganese, G ;

Maggiore, C ;

Evangelista, A ;

Rahimi, S ;

Zannoni, G ;

Vittori, G ;

Larocca, LM .

INTERNATIONAL JOURNAL OF CANCER, 2002, 102 (04) :398-406

← 1 2 3 4 5 6 7 8 →