Design and assembly of double-crossover linear arrays of micrometre length using rolling circle replication

被引：10

作者：

Lubrich, D ^{[1
]}

Bath, J ^{[1
]}

Turberfield, AJ ^{[1
]}

机构：

[1] Univ Oxford, Dept Phys, Clarendon Lab, Oxford OX1 3PU, England

来源：

NANOTECHNOLOGY | 2005年 / 16卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1088/0957-4484/16/9/028

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We demonstrate the use of rolling circle replication to template linear DNA arrays whose sizes bridge the gap between nanometre-scale self-assembly and top-down lithographic fabrication. Using rolling circle replication we have produced an oligonucleotide containing several hundred repeats of a short sequence motif. On this template we have constructed, by self-assembly, an array consisting of two parallel duplexes periodically linked by antiparallel Holliday junctions. We have observed arrays up to 10 mu m in length by atomic force microscopy.

引用

页码：1574 / 1577

页数：4

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