Ascorbate promotes low density lipoprotein oxidation in the presence of ferritin

被引：16

作者：

Dai, LI

Winyard, PG

Zhang, Z

Blake, DR

Morris, CJ

机构：

[1] ST BARTHOLOMEWS,INFLAMMAT RES GRP,LONDON E1 2AD,ENGLAND

[2] ROYAL LONDON SCH MED & DENT,LONDON E1 2AD,ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1996年 / 1304卷 / 03期

关键词：

ascorbate; ferritin; iron; LDL; lipoprotein oxidation; atherosclerosis;

D O I：

10.1016/S0005-2760(96)00121-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Whilst catalytic iron has been implicated in the development of atherosclerosis by initiating low density lipoprotein (LDL) oxidation, the source of such iron remains uncertain. Here, we show that LDL oxidation in the presence of ferritin was stimulated by ascorbate (15-60 mu M), whilst this effect was inhibited by the iron chelator desferrioxamine. Ascorbate also showed an antioxidant activity at high concentrations (125-250 mu M). Our results suggest that the combination of ascorbate with ferritin may supply free iron for LDL oxidation in vivo.

引用

收藏

页码：223 / 228

页数：6

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