Early expressed Clb proteins allow accumulation of mitotic cyclin by inactivating proteolytic machinery during S phase

被引：42

作者：

Yeong, FM ^{[1
]}

Lim, HH ^{[1
]}

Wang, Y ^{[1
]}

Surana, U ^{[1
]}

机构：

[1] Inst Mol & Cell Biol, Singapore 117609, Singapore

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2001年 / 21卷 / 15期

关键词：

D O I：

10.1128/MCB.21.15.5071-5081.2001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Periodic accumulation and destruction of mitotic cyclins are important for the initiation and termination of M phase. It is known that both APC(Cdc20) and APC(Hct1) collaborate to destroy mitotic cyclins during M phase. Here we show that this relationship between anaphase-promoting complex (APC) and Clb proteins is reversed in S phase such that the early Clb kinases (Clb3, Clb4, and Clb5 kinases) inactivate APC(Hct1) to allow Clb2 accumulation. This alternating antagonism between APC and Clb proteins during S and M phases constitutes an oscillatory system that generates undulations in the levels of mitotic cyclins.

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页码：5071 / 5081

页数：11

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