Topical versus intravenous tranexamic acid in total knee arthroplasty

被引：54

作者：

Hamlin, Brian R. ^{[1
]}

DiGioia, Anthony M. ^{[1
]}

Plakseychuk, Anton Y. ^{[1
]}

Levison, Tim J. ^{[1
]}

机构：

[1] Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Ctr Bone & Joint, Pittsburgh, PA 15213 USA

来源：

JOURNAL OF ARTHROPLASTY | 2015年 / 30卷 / 03期

关键词：

total knee arthroplasty; blood management; tranexamic acid; transfusion; complications; REDUCES BLOOD-LOSS; TOTAL HIP; TRANSFUSION RATES; CONTROLLED-TRIAL; METAANALYSIS; REPLACEMENT; RISK;

D O I：

10.1016/j.arth.2014.10.007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The objective of this study is to compare the effectiveness of intravenous versus topical application of tranexamic acid in patients undergoing knee arthroplasty. All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1 g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3 g TXA/100 mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P < 0.05). (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：384 / 386

页数：3

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