Therapeutic implications of cancer stem cells

被引：426

作者：

Al-Hajj, M

Becker, MW

Wichal, M

Weissman, I

Clarke, MF

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[3] Stanford Univ, Sch Med, Dept Pathol & Dev Biol, Beckman Ctr B 257, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.gde.2003.11.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Most cancers comprise a heterogenous population of cells with marked differences in their proliferative potential as well as the ability to reconstitute the tumor upon transplantation. Cancer stem cells are a minor population of tumor cells that possess the stem cell property of self-renewal. In addition, dysregulation of stem cell self-renewal is a likely requirement for the development of cancer. This new model for cancer will have significant ramifications for the way we study and treat cancer. In addition, through targeting the cancer stem cell and its dysregulated self-renewal, our therapies for treating cancer are likely to improve.

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页码：43 / 47

页数：5

相关论文

共 46 条

[1] CD24, a mucin-type glycoprotein, is a ligand for P-selectin on human tumor cells [J].

Aigner, S ;

Sthoeger, ZM ;

Fogel, M ;

Weber, E ;

Zarn, J ;

Ruppert, M ;

Zeller, Y ;

Vestweber, D ;

Stahel, R ;

Sammar, M ;

Altevogt, P .

BLOOD, 1997, 89 (09) :3385-3395

[2] A clonogenic common myeloid progenitor that gives rise to all myeloid lineages [J].

Akashi, K ;

Traver, D ;

Miyamoto, T ;

Weissman, IL .

NATURE, 2000, 404 (6774) :193-197

[3] Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis [J].

Akashi, K ;

He, X ;

Chen, J ;

Iwasaki, H ;

Niu, C ;

Steenhard, B ;

Zhang, JW ;

Haug, J ;

Li, LH .

BLOOD, 2003, 101 (02) :383-390

[4]

AKASHI K, 2001, DEV BIOL HEMATOPOIES

[5] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[6] WNT signals are required for the initiation of hair follicle development [J].

Andl, T ;

Reddy, ST ;

Gaddapara, T ;

Millar, SE .

DEVELOPMENTAL CELL, 2002, 2 (05) :643-653

[7] A role for the Wnt gene family in hematopoiesis: Expansion of multilineage progenitor cells [J].

Austin, TW ;

Solar, GP ;

Ziegler, FC ;

Liem, L ;

Matthews, W .

BLOOD, 1997, 89 (10) :3624-3635

[8] ISOLATION OF A CANDIDATE HUMAN HEMATOPOIETIC STEM-CELL POPULATION [J].

BAUM, CM ;

WEISSMAN, IL ;

TSUKAMOTO, AS ;

BUCKLE, AM ;

PEAULT, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :2804-2808

[9]

BEDI A, 1993, BLOOD, V81, P2898

[10] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J].

Bhardwaj, G ;

Murdoch, B ;

Wu, D ;

Baker, DP ;

Williams, KP ;

Chadwick, K ;

Ling, LE ;

Karanu, FN ;

Bhatia, M .

NATURE IMMUNOLOGY, 2001, 2 (02) :172-180

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