Gigantransenins A, B, and C, novel mono-THF acetogenins bearing trans double bonds, from Goniothalamus giganteus (Annonaceae)

被引：16

作者：

Zeng, L ^{[1
]}

Zhang, Y ^{[1
]}

McLaughlin, JL ^{[1
]}

机构：

[1] PURDUE UNIV,SCH PHARM & PHARMACAL SCI,DEPT MED CHEM & MOL PHARMACOL,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 31期

关键词：

D O I：

10.1016/0040-4039(96)01191-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel bioactive acetogenins, gigantransenins A (1), B (2), and C (3), were isolated from the bark of Goniothalamus giganteus (Annonaceae). 1-3 are C-37 mono-tetrahydrofuran (THF) acetogenins each having a trans double bond; their absolute structures were elucidated by spectral and spectroscopic analyses and derivatizations. No Annonaceous acetogenins having trans double bonds have been reported previously. 1-3 showed selective inhibitory effects on the human breast tumor cell line (MCF-7) that are comparable with the potency of adriamycin. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5449 / 5452

页数：4

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