Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists

被引：24

作者：

Xin, ZL ^{[1
]}

Zhao, HY ^{[1
]}

Serby, MD ^{[1
]}

Liu, B ^{[1
]}

Schaefer, VG ^{[1
]}

Falls, DH ^{[1
]}

Kaszubska, W ^{[1
]}

Colins, CA ^{[1
]}

Sham, HL ^{[1
]}

Liu, G ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut Res & Dev, Metab Dis Res, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

growth hormone secretagogue receptor antagonist;

D O I：

10.1016/j.bmcl.2004.11.075

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1201 / 1204

页数：4

共 12 条

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