A new class of sulfoxide surfactants derived from tris.: Synthesis and preliminary assessments of their properties.

被引:20
作者
Barthélémy, P
Maurizis, JC
Lacombe, JM
Pucci, B
机构
[1] Univ Avignon, Lab Chim Bioorgan & Syst Mol Vectoriels, F-84000 Avignon, France
[2] INSERM, U71, F-63005 Clermont Ferrand, France
关键词
non-ionic surfactant; perfluoroalkyl surfactant; Tris; sulfoxide; protein extraction;
D O I
10.1016/S0960-894X(98)00263-7
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new class of non-ionic amphiphilic molecules suitable for biological purposes, especially extraction of membrane proteins, is reported. Such surfactants were prepared in two steps : addition of alkyl or fluoroalkyl mercaptan on Tris(hydroxymethyl)acrylamidomethane (THAM) derivatives, followed by the oxydation of sulfide group in sulfoxide moiety in order to provide water solubility to the molecule. The detergent efficiency of these new surfactants were assayed on rat liver cells. (C) 1998 Elsevier Science Ltd. All nights reserved.
引用
收藏
页码:1559 / 1562
页数:4
相关论文
共 7 条
[1]   SYNTHESIS OF SULFOXIDES - A REVIEW [J].
DRABOWICZ, J ;
MIKOLAJCZYK, M .
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1982, 14 (1-2) :45-89
[2]   SYNTHESIS OF SULFOXIDES BY OXIDATION OF THIOETHERS [J].
MADESCLAIRE, M .
TETRAHEDRON, 1986, 42 (20) :5459-5495
[3]  
PAVIA AA, 1992, MAKROMOL CHEM, V193, P2505
[4]  
POLIDORI A, 1994, NEW J CHEM, V18, P839
[5]   TELOMERS AND COTELOMERS OF BIOLOGICAL AND BIOMEDICAL SIGNIFICANCE .4. TELOMERS OF TRIS(HYDROXYMETHYL)ACRYLAMIDOMETHANE, NEW NONIONIC AMPHIPHILIC AGENTS [J].
PUCCI, B ;
MAURIZIS, JC ;
PAVIA, AA .
EUROPEAN POLYMER JOURNAL, 1991, 27 (10) :1101-1106
[6]  
PUCCI B, 1997, Patent No. 978701308
[7]  
SHAW J, 1980, INTRO COLLOID SURFAC