Bench-to-bedside review: Molecular pharmacology and clinical use of inert gases in anesthesia and neuroprotection

被引：89

作者：

Dickinson, Robert ^{[1
,2
]}

Franks, Nicholas P. ^{[1
,2
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, Biophys Sect, London SW7 2AZ, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Anaesthet Pain Med & Intens Care, London SW10 9NH, England

来源：

CRITICAL CARE | 2010年 / 14卷 / 04期

关键词：

MINIMUM ALVEOLAR CONCENTRATION; NICOTINIC ACETYLCHOLINE-RECEPTOR; RANDOMIZED CONTROLLED-TRIAL; CEREBRAL-ARTERY OCCLUSION; D-ASPARTATE RECEPTOR; GATED ION CHANNELS; IN-VITRO MODEL; NITROUS-OXIDE; XENON ANESTHESIA; CARDIOPULMONARY BYPASS;

D O I：

10.1186/cc9051

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

In the past decade there has been a resurgence of interest in the clinical use of inert gases. In the present paper we review the use of inert gases as anesthetics and neuroprotectants, with particular attention to the clinical use of xenon. We discuss recent advances in understanding the molecular pharmacology of xenon and we highlight specific pharmacological targets that may mediate its actions as an anesthetic and neuroprotectant. We summarize recent in vitro and in vivo studies on the actions of helium and the other inert gases, and discuss their potential to be used as neuroprotective agents.

引用

页数：12

共 110 条

[1]

Potentially neuroprotective and therapeutic properties of nitrous oxide and xenon [J].