Macaques with rapid disease progression and simian immunodeficiency virus encephalitis have a unique cytokine profile in peripheral lymphoid tissues

被引：46

作者：

Orandle, AS ^{[1
]}

Williams, KC ^{[1
]}

MacLean, AG ^{[1
]}

Westmoreland, SV ^{[1
]}

Lackner, AA ^{[1
]}

机构：

[1] Harvard Univ, New England Reg Primate Res Ctr, Sch Med, Div Comparat Pathol, Southborough, MA 01772 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 09期

关键词：

D O I：

10.1128/JVI.75.9.4448-4452.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influence of host cytokine response on viral load, disease progression, and neurologic lesions was investigated in the simian immunodeficiency virus (SIV)-infected macaque model of AIDS. Cytokine gene expression (interleukin-1 beta [IL-1 beta], IL 2, IL-6, IL-10, gamma interferon [IFN-gamma], and tumor necrosis factor alpha [TNF-alpha]) and viral Loads were evaluated by semiquantitative reverse transcription-PCR in lymph nodes of 5 control animals and 28 animals infected with SIVmac251 at the terminal stages of AIDS. Infected animals showed higher expression of IFN-gamma, IL-6, and IL-10 mRNAs compared with controls. Levels of all cytokines were comparable between animals with rapid (survival, < 200 days) or slow/normal (survival, > 200 days) disease progression. However, among rapid progressors, the eight animals with SN encephalitis had a unique cytokine profile (increased IL-2, IL-6, and IFN-gamma) that was associated with higher viral loads. These observations provide evidence that host cytokine responses may influence SIV neuropathogenesis independent of disease progression.

引用

页码：4448 / 4452

页数：5

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