Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

被引：91

作者：

Bali, A

Bansal, Y

Sugumaran, M

Saggu, JS

Balakumar, P

Kaur, G

Bansal, G ^{[1
]}

Sharma, A

Singh, M

机构：

[1] Punjab Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjabi, India

[2] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[3] Zydus Cadila Ltd, Div Pharmacol, Ahmadabad, Gujarat, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

5-substituted benzimidazole; angiotensin II; antagonists; Candesartan; Losartan;

D O I：

10.1016/j.bmcl.2005.05.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug-receptor interaction model has been proposed. (c) 2005 Published by Elsevier Ltd.

引用

收藏

页码：3962 / 3965

页数：4

相关论文

共 16 条

[1]

NONPEPTIDE ANGIOTENSIN-II ANTAGONISTS DERIVED FROM 4H-1,2,4-TRIAZOLES AND 3H-IMIDAZO[1,2-B][1,2,4]TRIAZOLES [J].

ASHTON, WT ;

CANTONE, CL ;

CHANG, LL ;

HUTCHINS, SM ;

STRELITZ, RA ;

MACCOSS, M ;

CHANG, RSL ;

LOTTI, VJ ;

FAUST, KA ;

CHEN, TB ;

BUNTING, P ;

SCHORN, TW ;

KIVLIGHN, SD ;

SIEGL, PKS .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (05) :591-609

[2]

AN INTERPRETATION OF META ORIENTATION IN THE ALKYLATION OF TOLUENE - THE RELATIVE REACTIVITY AND ISOMER DISTRIBUTION IN THE CHLOROMETHYLATION AND MERCURATION OF BENZENE AND TOLUENE [J].

BROWN, HC ;

NELSON, KL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1953, 75 (24) :6292-6299

[3]

NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - THE DISCOVERY OF A SERIES OF N-(BIPHENYLYLMETHYL)IMIDAZOLES AS POTENT, ORALLY ACTIVE ANTIHYPERTENSIVES [J].

CARINI, DJ ;

DUNCIA, JV ;

ALDRICH, PE ;

CHIU, AT ;

JOHNSON, AL ;

PIERCE, ME ;

PRICE, WA ;

SANTELLA, JB ;

WELLS, GJ ;

WEXLER, RR ;

WONG, PC ;

YOO, SE ;

TIMMERMANS, PBMWM .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (08) :2525-2547

[4]

THE DISCOVERY OF POTENT NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - A NEW CLASS OF POTENT ANTIHYPERTENSIVES [J].

DUNCIA, JV ;

CHIU, AT ;

CARINI, DJ ;

GREGORY, GB ;

JOHNSON, AL ;

PRICE, WA ;

WELLS, GJ ;

WONG, PC ;

CALABRESE, JC ;

TIMMERMANS, PBMWM .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1312-1329

[5]

ULLMANN SYNTHESIS OF BIARYLS 1945-1963 [J].

FANTA, PE .

CHEMICAL REVIEWS, 1964, 64 (06) :613-&

[6]

The synthesis of biaryl compounds by means of the diazo reaction [J].

Gomberg, M ;

Bachmann, WE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1924, 46 :2339-2343

[7]

GRIMMETT MR, 1984, COMPR HETEROCYCL C 1, V5, P429

[8]

KAGEYAMA H, 1994, SYNLETT, P371

[9]

REACTIONS BETWEEN STRONGLY BASIC NUCLEOPHILES AND FLUORENONES [J].

KENNER, GW ;

ROBINSON, MJ ;

TYLOR, CMB ;

WEBSTER, BR .

JOURNAL OF THE CHEMICAL SOCIETY, 1962, (MAY) :1756-&

[10]

NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY OF BENZIMIDAZOLECARBOXYLIC ACIDS [J].

KUBO, K ;

KOHARA, Y ;

IMAMIYA, E ;

SUGIURA, Y ;

INADA, Y ;

FURUKAWA, Y ;

NISHIKAWA, K ;

NAKA, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (15) :2182-2195