Further evidence for direct vascular actions of statins: Effect on endothelial nitric oxide synthase and adhesion molecules

被引：41

作者：

Mueck, AO ^{[1
]}

Seeger, H ^{[1
]}

Wallwiener, D ^{[1
]}

机构：

[1] Univ Tubingen, Dept Obstet & Gynecol, Sect Gynecol Endocrinol & Menopause, D-72076 Tubingen, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2001年 / 109卷 / 03期

关键词：

fluvastatin; endothelial nitric oxide synthase; adhesion molecules;

D O I：

10.1055/s-2001-14843

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of the synthetic statin fluvastatin was investigated on the concentrations of endothelial nitric oxide synthase (eNOS) and of soluble adhesion molecules in human vascular endothelial cell cultures. Fluvastatin was able to increase dose-dependently eNOS concentration. In addition, fluvastatin reduced concentrations of E-Selectin and ICAM-1. These results further support the evidence that statins elicit important effects on the vascular endothelium which may contribute to the reduction of morbidity and mortality of cardiovascular diseases.

引用

页码：181 / 183

页数：3

共 7 条

[1] HMG CoA reductase inhibitors reduce plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells [J].