Myelin Regeneration: A Recapitulation of Development?

被引：247

作者：

Fancy, Stephen P. J. ^{[1
,2
,3
]}

Chan, Jonah R. ^{[4
]}

Baranzini, Sergio E. ^{[4
]}

Franklin, Robin J. M. ^{[6
,7
]}

Rowitch, David H. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, Eli & Edyth Broad Inst Stem Cell Res & Regenerat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurosurg, Eli & Edyth Broad Inst Stem Cell Res & Regenerat, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Div Neonatol, San Francisco, CA 94143 USA

[6] Univ Cambridge, MRC Ctr Stem Cell Biol & Regenerat Med, Cambridge CB3 0ES, England

[7] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

来源：

ANNUAL REVIEW OF NEUROSCIENCE, VOL 34 | 2011年 / 34卷

关键词：

myelination; remyelination; multiple sclerosis; oligodendrocyte; CNS development; OLIGODENDROCYTE PRECURSOR CELLS; NERVOUS-SYSTEM REMYELINATION; SPINAL-CORD; MULTIPLE-SCLEROSIS; CNS REMYELINATION; PROGENITOR CELLS; AUTOIMMUNE ENCEPHALOMYELITIS; DEMYELINATED LESIONS; SUBVENTRICULAR ZONE; MAMMALIAN TARGET;

D O I：

10.1146/annurev-neuro-061010-113629

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The developmental process of myelination and the adult regenerative process of remyelination share the common objective of investing nerve axons with myelin sheaths. A central question in myelin biology is the extent to which the mechanisms of these two processes are conserved, a concept encapsulated in the recapitulation hypothesis of remyelination. This question also has relevance for translating myelin biology into a better understanding of and eventual treatments for human myelin disorders. Here we review the current evidence for the recapitulation hypothesis and discuss recent findings in the development and regeneration of myelin in the context of human neurological disease.

引用

页码：21 / 43

页数：23

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