Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine

被引：30

作者：

Co, Mary Dawn T. ^{[1
]}

Orphin, Laura ^{[1
]}

Cruz, John ^{[1
]}

Pazoles, Pamela ^{[1
]}

Rothman, Alan L. ^{[1
]}

Ennis, Francis A. ^{[1
]}

Terajima, Masanori ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Ctr Infect Dis & Vacine Res, Worcester, MA 01655 USA

来源：

VACCINE | 2008年 / 26卷 / 16期

关键词：

B cells; T cells; influenza;

D O I：

10.1016/j.vaccine.2008.02.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFN-gamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFN gamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1990 / 1998

页数：9

共 41 条

[1]

Arlettaz L, 1999, EUR J IMMUNOL, V29, P3987, DOI 10.1002/(SICI)1521-4141(199912)29:12<3987::AID-IMMU3987>3.0.CO

[2]

2-4

[3] AN INFLUENZA SPECIFIC T-KILLER CLONE IS RESTRICTED TO H-2LD AND CROSS-REACTS WITH DK REGION [J].

ASKONAS, BA ;

LIN, YL .

IMMUNOGENETICS, 1982, 16 (01) :83-87

[4] Safety, efficacy and effectiveness of cold-adapted, live, attenuated, trivalent, intranasal influenza vaccine in adults and children [J].

Belshe, RB ;

Gruber, WC .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2001, 356 (1416) :1947-1951

[5] Compromised influenza virus-specific CD8+-T-Cell memory in CD4+-T-cell-deficient mice [J].

Belz, GT ;

Wodarz, D ;

Diaz, G ;

Nowak, MA ;

Doherty, PC .

JOURNAL OF VIROLOGY, 2002, 76 (23) :12388-12393

[6] TRANSGENIC MICE LACKING CLASS-I MAJOR HISTOCOMPATIBILITY COMPLEX-RESTRICTED T-CELLS HAVE DELAYED VIRAL CLEARANCE AND INCREASED MORTALITY AFTER INFLUENZA-VIRUS CHALLENGE [J].

BENDER, BS ;

CROGHAN, T ;

ZHANG, LP ;

SMALL, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (04) :1143-1145

[7]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[8] Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cells [J].

Catalina, MD ;

Sullivan, JL ;

Brody, RM ;

Luzuriaga, K .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :4184-4191

[9] A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays [J].

Currier, JR ;

Kuta, EG ;

Turk, E ;

Earhart, LB ;

Loomis-Price, L ;

Janetzki, S ;

Ferrari, G ;

Birx, DL ;

Cox, JH .

JOURNAL OF IMMUNOLOGICAL METHODS, 2002, 260 (1-2) :157-172

[10] Age-related impaired type 1 T cell responses to influenza: Reduced activation ex vivo, decreased expansion in CTL culture in vitro, and blunted response to influenza vaccination in vivo in the elderly [J].

Deng, YP ;

Jing, Y ;

Campbell, AE ;

Gravenstein, S .

JOURNAL OF IMMUNOLOGY, 2004, 172 (06) :3437-3446

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