Axinellamines A-D, novel imidazo-azolo-imidazole alkaloids from the Australian marine sponge Axinella sp.

被引：111

作者：

Urban, S

Leone, PD

Carroll, AR

Fechner, GA

Smith, J

Hooper, JNA

Quinn, RJ ^{[1
]}

机构：

[1] Griffith Univ, Queensland Pharmaceut Res Inst, Brisbane, Qld 4111, Australia

[2] Queensland Museum, S Brisbane, Qld 4101, Australia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 03期

关键词：

D O I：

10.1021/jo981034g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four imidazo-azolo-imidazole alkaloids, axinellamines A-D, have been isolated from an Australian marine sponge, Axinella sp. (order: Halichondrida: family: Axinellidae). These compounds contain a unique perhydrocyclopenta-imidazo-azolo-imidazole carbon skeleton. Three of these compounds had bactericidal activity against Helicobacter pylori at 1000 mu M.

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页码：731 / 735

页数：5

相关论文

共 8 条

[1] Eudistomin V, a new β-carboline from the Australian ascidian Pseudodistoma aureum [J].

Davis, RA ;

Carroll, AR ;

Quinn, RJ .

JOURNAL OF NATURAL PRODUCTS, 1998, 61 (07) :959-960

[2] ASSIGNMENT OF THE C-13 NMR SHIFTS OF BROMINATED PYRROLE DERIVATIVES [J].

FOLEY, LH ;

HABGOOD, GJ ;

GALLAGHER, KS .

MAGNETIC RESONANCE IN CHEMISTRY, 1988, 26 (11) :1037-1038

[3] STYLOGUANIDINES, NEW CHITINASE INHIBITORS FROM THE MARINE SPONGE STYLOTELLA-AURANTIUM [J].

KATO, T ;

SHIZURI, Y ;

IZUMIDA, H ;

YOKOYAMA, A ;

ENDO, M .

TETRAHEDRON LETTERS, 1995, 36 (12) :2133-2136

[4] BIOACTIVE BROMOPYRROLE METABOLITES FROM THE CARIBBEAN SPONGE AGELAS-CONIFERA [J].

KEIFER, PA ;

SCHWARTZ, RE ;

KOKER, MES ;

HUGHES, RG ;

RITTSCHOF, D ;

RINEHART, KL .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (09) :2965-2975

[5] A NOVEL ANTAGONIST OF SEROTONERGIC RECEPTORS, HYMENIDIN, ISOLATED FROM THE OKINAWAN MARINE SPONGE HYMENIACIDON SP [J].

KOBAYASHI, J ;

OHIZUMI, Y ;

NAKAMURA, H ;

HIRATA, Y .

EXPERIENTIA, 1986, 42 (10) :1176-1177

[6] HYMENIN, A NOVEL ALPHA-ADRENOCEPTOR BLOCKING-AGENT FROM THE OKINAWAN MARINE SPONGE HYMENIACIDON SP [J].

KOBAYASHI, J ;

OHIZUMI, Y ;

NAKAMURA, H ;

HIRATA, Y ;

WAKAMATSU, K ;

MIYAZAWA, T .

EXPERIENTIA, 1986, 42 (09) :1064-1065

[7] SCEPTRIN, AN ANTIMICROBIAL AGENT FROM THE SPONGE AGELAS-SCEPTRUM [J].

WALKER, RP ;

FAULKNER, DJ ;

VANENGEN, D ;

CLARDY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (22) :6772-6773

[8] N-methylated ageliferins from the sponge Astrosclera willeyana from Pohnpei [J].

Williams, DH ;

Faulkner, DJ .

TETRAHEDRON, 1996, 52 (15) :5381-5390