Endoproteinase-protein inhibitor interactions

被引:34
作者
Bode, W [1 ]
Fernandez-Catalan, C
Nagase, H
Maskos, K
机构
[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany
[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS USA
关键词
proteinases; proteinase-inhibitor complexes; matrix metalloproteinases (MMPs); tissue inhibitors of metalloproteinases (TIMPs); protein inhibitors; crystal structures;
D O I
10.1111/j.1699-0463.1999.tb01520.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Nature uses protein inhibitors as important tools to regulate the proteolytic activity of their target proteinases. Most of these inhibitors for which 3D structures are available are directed towards serine proteinases, interacting with their active-sites in a substrate-like "canonical" manner via an exposed reactive-site loop of conserved conformation. More recently, some non-canonically binding serine proteinase inhibitors, two cysteine proteinase inhibitors, and three zinc endopeptidase inhibitors have been characterized in the free and complexed state, displaying novel mechanisms of inhibition with their target proteinases. These different interaction modes are briefly discussed, with particular emphasis on the interaction between matrix metalloproteinases (MMPs) and their endogenous tissue inhibitors of metalloproteinases (TIMPs).
引用
收藏
页码:3 / 10
页数:8
相关论文
共 40 条
  • [1] STROMELYSIN-1 - 3-DIMENSIONAL STRUCTURE OF THE INHIBITED CATALYTIC DOMAIN AND OF THE C-TRUNCATED PROENZYME
    BECKER, JW
    MARCY, AI
    ROKOSZ, LL
    AXEL, MG
    BURBAUM, JJ
    FITZGERALD, PMD
    CAMERON, PM
    ESSER, CK
    HAGMANN, WK
    HERMES, JD
    SPRINGER, JP
    [J]. PROTEIN SCIENCE, 1995, 4 (10) : 1966 - 1976
  • [2] THE REFINED 1.9 A CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN - INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT
    BODE, W
    MAYR, I
    BAUMANN, U
    HUBER, R
    STONE, SR
    HOFSTEENGE, J
    [J]. EMBO JOURNAL, 1989, 8 (11) : 3467 - 3475
  • [3] A HELPING HAND FOR COLLAGENASES - THE HEMOPEXIN-LIKE DOMAIN
    BODE, W
    [J]. STRUCTURE, 1995, 3 (06) : 527 - 530
  • [4] PROTEINASE - PROTEIN INHIBITOR INTERACTIONS
    BODE, W
    HUBER, R
    [J]. FIBRINOLYSIS, 1994, 8 : 161 - 171
  • [6] THE 2.0 A X-RAY CRYSTAL-STRUCTURE OF CHICKEN EGG-WHITE CYSTATIN AND ITS POSSIBLE MODE OF INTERACTION WITH CYSTEINE PROTEINASES
    BODE, W
    ENGH, R
    MUSIL, D
    THIELE, U
    HUBER, R
    KARSHIKOV, A
    BRZIN, J
    KOS, J
    TURK, V
    [J]. EMBO JOURNAL, 1988, 7 (08) : 2593 - 2599
  • [7] ASTACINS, SERRALYSINS, SNAKE-VENOM AND MATRIX METALLOPROTEINASES EXHIBIT IDENTICAL ZINC-BINDING ENVIRONMENTS (HEXXHXXGXXH AND MET-TURN) AND TOPOLOGIES AND SHOULD BE GROUPED INTO A COMMON FAMILY, THE METZINCINS
    BODE, W
    GOMISRUTH, FX
    STOCKLER, W
    [J]. FEBS LETTERS, 1993, 331 (1-2) : 134 - 140
  • [8] NATURAL PROTEIN PROTEINASE-INHIBITORS AND THEIR INTERACTION WITH PROTEINASES
    BODE, W
    HUBER, R
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 204 (02): : 433 - 451
  • [9] BODE W, 1992, PROTEIN SCI, V1, P426
  • [10] Carrell RW, 1996, BIOL CHEM H-S, V377, P1