Atomarianones A and B:: two cytotoxic meroditerpenes from the brown alga Taonia atomaria

被引：21

作者：

Abatis, D

Vagias, C

Galanakis, D

Norris, JN

Moreau, D

Roussakis, C

Roussis, V ^{[1
]}

机构：

[1] Univ Athens, Sch Pharm, Dept Pharmacognosy & Chem Nat Prod, GR-15771 Athens, Greece

[2] Aristotle Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece

[3] Smithsonian Inst, Natl Museum Nat Hist, Dept Bot, Washington, DC 20013 USA

[4] ISOMer, Lab Pharmacogenom Marine, Fac Pharm, F-44035 Nantes, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 49期

关键词：

Taonia atomaria; meroditerpenes; atomarianones; cytotoxic; chemotaxonomy;

D O I：

10.1016/j.tetlet.2005.10.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel cyclized meroditerpenoids atomarianones A, and B (I and 2), were isolated from the organic extract of the brown alga Taonia atomaria collected at Serifos island in the Central Aegean Sea. This is only the second report on metabolites having a functionalized indane moiety instead of a benzofurano- or a benzopyrano-ring connecting their aromatic and diterpenoid parts. Atomarianone A contains an unprecedented cis B-C ring fusion while atomarianone B is the epimer of A at C-7. Both metabolites were found to exhibit significant cytotoxic activity against two lung cancer cell lines. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8525 / 8529

页数：5

共 34 条

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