Antiinflammatory Effects of Ginger and Some of its Components in Human Bronchial Epithelial (BEAS-2B) Cells

被引：32

作者：

Podlogar, Julia A. ^{[1
]}

Verspohl, Eugen J. ^{[1
]}

机构：

[1] Univ Munster, Inst Med Chem, Dept Pharmacol, D-48149 Munster, Germany

来源：

PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 03期

关键词：

ginger; BEAS-2B; IL-8; RANTES; antiinflammatory; ZINGIBER-OFFICINALE; EXTRACT; RHIZOMES;

D O I：

10.1002/ptr.3558

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The proinflammatory chemokine interleukin-8 is increased in asthmatic patients. Traditionally, ginger is used as an antiinflammatory drug. An extract and several compounds of Zingiber officinale (ginger) were tested in human bronchial epithelial cells (BEAS-2B cells) with respect to their effect on lipopolysaccharide (LPS)-induced secretion of the proinflammatory chemokine interleukin?8 (IL-8) and RANTES (regulated upon activation, normal T-cell expressed and secreted). An oily extract of ginger rhizome with?>?25% total pungent compounds, ginger volatile oil, ar-curcumene and a-pinene reduced the LPS-induced IL-8 secretion (measured by a specific enzyme-linked immunosorbent assay), whereas a spissum extract, the pungents [6]-gingerol and its metabolite [6]-shogaol, and the terpenoids citral and beta-phellandrene showed no effect. The LPS-induced slight increase of RANTES was reduced by volatile oil, ar-curcumene and a-pinene. There was no effect of LPS on TNF-a. Our results suggest that distinct ginger compounds could be used as antiinflammatory drugs in respiratory infections. Copyright (c) 2011 John Wiley & Sons, Ltd.

引用

页码：333 / 336

页数：4

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