Transcription factors in autoimmunity

被引：52

作者：

Ramsdell, F

Ziegler, SF

机构：

[1] Celtech R&D Inc, Bothell, WA 98021 USA

[2] Benaroya Res Inst Virginia Mason, Seattle, WA 98101 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.coi.2003.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification of two transcription factors that, when mutated, are responsible for severe autoimmune disease in humans is leading to a better understanding of the fundamental processes involved in T-cell tolerance. Both AIRE and FOXP3, identified initially via their association with genetically manipulated mice, are critically involved in tolerance induction in humans. Although mutations in these genes may cause rare but serious diseases, it is likely that other transcription factors will contribute to the genetic load that predisposes certain individuals to disease.

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收藏

页码：718 / 724

页数：7

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